This learning activity prepares school nurses to address the opioid crisis through evidence-based prevention, emergency intervention, and advocacy strategies. Content covers current synthetic opioid trends, SBIRT screening protocols, naloxone administration, and multi-tiered support systems for at-risk students. Participants learn to recognize overdose signs, establish emergency protocols, coordinate treatment referrals, and create stigma-free environments that encourage help-seeking. The activity emphasizes the school nurse's expanded role as first responder, educator, and policy advocate while addressing documentation requirements, staff training, and professional development needs essential for effective substance use intervention in educational settings.