This learning activity explores how artificial intelligence (AI) is transforming nursing practice across multiple domains while emphasizing that technology serves to enhance rather than replace nursing judgment and compassionate care. It examines AI applications in clinical decision support, documentation, predictive analytics, medication management, telehealth, and patient education. The learning activity addresses challenges including data privacy, depersonalization of care, and algorithmic bias, while emphasizing the importance of digital competency development. Throughout, it reinforces that despite technological advancement, the core of nursing remains constant: patient advocacy, integration of scientific knowledge with compassionate care, and focus on health promotion and prevention.