This learning activity explores the prevalence of lower back pain (LBP) among healthcare workers, examining its multifactorial etiology, including occupational and individual risk factors. It discusses prevention strategies such as ergonomic interventions, safe patient handling, wellness programs, and early intervention, as well as management options like exercise, physical therapy, ergonomic modifications, and return-to-work programs. The learning activity emphasizes the importance of prioritizing healthcare worker safety through evidence-based prevention and management strategies to create a safer work environment and improve patient care quality.