This evidence-based educational resource examines burnout prevention and resilience-building for surgical nurses in ambulatory settings. It provides a comprehensive multi-level approach addressing individual strategies (cognitive reframing, mindfulness, communication templates), organizational interventions (staffing models, workflow redesign, leadership practices), and systemic approaches to combat burnout. Using current research and professional guidelines, it offers practical, implementable solutions to enhance nurse well-being while improving patient outcomes and organizational efficiency.