This learning activity provides pediatric nurses with a current, evidence-based overview of developmental disabilities - including autism spectrum disorder, ADHD, intellectual disability/global developmental delay, and cerebral palsy - spanning epidemiology, surveillance and screening guidelines, precision diagnostics (including genetic testing and emerging FDA-cleared tools), and family-centered care planning through the nursing process. Emphasizing functional assessment, co-occurring conditions, health equity, and transition to adulthood, the activity equips nurses to apply current AAP and ACMG guidance and integrate a lifespan, whole-child perspective into practice across care settings.