This evidence-based learning activity equips nurses with essential knowledge and practical strategies for managing emerging infectious diseases, including influenza, H5N1, COVID-19, antimicrobial-resistant organisms, and viral hemorrhagic fevers. Drawing from current CDC surveillance data, the content emphasizes age-specific nursing considerations across the lifespan, covering core competencies in surveillance, infection prevention and control, psychological preparedness, and interprofessional collaboration during outbreak responses. Designed specifically for nursing professionals, the learning activity bridges theoretical knowledge with practical application, focusing on the nurse's critical role as frontline responder and patient advocate while adapting evidence-based protocols for different patient populations and maintaining therapeutic relationships during high-stress situations.