This learning activity provides a comprehensive overview of hereditary hemochromatosis, a common genetic disorder characterized by excessive iron absorption and storage in the body. It covers the epidemiology, pathophysiology, clinical presentation, screening and diagnosis, management, and prognosis of the condition. The learning activity emphasizes the importance of early recognition and treatment to prevent irreversible organ damage and improve patient outcomes. It also highlights the crucial role of nurses in identifying at-risk patients, promoting timely diagnostic testing, and providing education on lifelong management strategies.