This learning activity explores hormonal regulation as a foundation of nursing care, examining endocrine transitions and imbalances from adolescence through menopause. It integrates physiological principles with practical clinical applications, addressing how hormonal conditions manifest differently across life stages while sharing underlying mechanisms. Nurses will gain advanced assessment skills to recognize subtle signs of endocrine dysfunction, understand environmental influences on hormonal health, and develop holistic care approaches that address both physiological and psychosocial dimensions of patient experience.