This comprehensive learning activity examines latex allergies in healthcare settings, beginning with a case study of an OR nurse experiencing an acute reaction. It covers the mechanisms of latex allergy, including three types of reactions, and identifies high-risk populations such as children with spina bifida, healthcare workers, and patients requiring multiple surgeries. The text explores latex-fruit cross-reactivity, the creation of latex-safe environments, emergency response protocols, and proper documentation practices. Throughout, it emphasizes the significance of latex sensitivity as an occupational hazard, noting its higher prevalence among healthcare workers (up to 17%) compared to the general population (1-7%), while providing practical guidance for managing this risk in medical settings.