This learning activity examines the perioperative nursing management of multimorbid patients in the ambulatory surgery setting, covering evidence-based strategies across the full continuum of care - from preoperative optimization and prehabilitation through intraoperative management, postoperative monitoring, and safe care transitions. Topics include risk stratification, frailty assessment, high-risk medication management, comorbidity cluster considerations, discharge criteria, and readmission prevention, with guidance grounded in current standards from AORN, ASPAN, ACC/AHA, SAMBA, ADA, and The Joint Commission.