This learning activity examines medical device integration and interoperability in nursing practice, focusing on how connected devices communicate with electronic health records and healthcare systems. Nurses will learn the four levels of interoperability, key standards including HL7 FHIR and IEEE 11073, and current trends such as real-time surveillance and closed-loop medication administration. The content addresses practical challenges including alert fatigue, data accuracy verification, troubleshooting integration failures, and cybersecurity concerns while emphasizing the importance of clinical judgment with automated systems. Through clinical scenarios and actionable strategies, this activity prepares nurses to effectively use integrated medical devices, participate in technology optimization, and maintain patient-centered care amid increasing digitization of healthcare delivery.