This learning activity prepares nurses to recognize and respond to the behavioral health needs woven into chronic illness care. It covers the bidirectional relationship between mental and physical health, evidence-based screening tools for depression, anxiety, suicide risk, and substance use, therapeutic communication and motivational interviewing techniques for supporting behavior change, and the trauma-informed, person-centered, and interdisciplinary approaches, including emerging value-based payment models, that are reshaping how this care is organized and delivered.