This learning activity explores the use of mindfulness as an evidence-based tool for managing stress and improving patient care in nursing practice. The learning activity examines the neurobiological basis of mindfulness, its documented benefits for healthcare professionals, and practical techniques for implementation during clinical shifts. Drawing from current research, it addresses the critical issues of nurse burnout and workplace stress while providing concrete strategies for building emotional resilience and maintaining presence in high-pressure healthcare environments. Content includes the impact of stress on nurse well-being, the science behind mindfulness practices, and specific mindfulness exercises adapted for busy clinical settings.