In the quiet corridors of neonatal units across America, a distinct cry echoes - one that tells the story of our nation's ongoing opioid crisis through its smallest victims. This comprehensive learning activity walks healthcare professionals through the intricate journey of caring for infants with Neonatal Abstinence Syndrome (NAS), weaving together clinical expertise with compassionate care strategies. From the tell-tale signs of withdrawal to the latest evidence-based treatments, the text serves as both a clinical roadmap and a reminder of the profound impact nurses have in these critical early days. It explores the delicate dance of managing symptoms while supporting families, emphasizing that success lies not only in medical intervention but in creating a foundation of understanding and support that extends well beyond the hospital walls.