This learning activity examines evidence-based, non-opioid approaches to chronic pain management across the lifespan, equipping nurses with the clinical knowledge and practical tools needed to assess, manage, and advocate for patients experiencing chronic pain. Drawing on current CDC, ACP, and Joint Commission guidelines, the activity covers the epidemiology of chronic pain, pharmacological and non-pharmacological treatment alternatives, population-specific considerations for adolescent, adult, and aging adult patients, and emerging trends shaping the future of pain care.