This learning activity examines patient-centered pre-admission screening strategies for ambulatory surgery, focusing on five transformative trends: digital and telehealth-enabled platforms, AI-enhanced risk scoring, holistic assessment incorporating functional status and social determinants, palliative care and health equity screening, and plain language patient education. Grounded in current ACC/AHA, ADA, Joint Commission, and AACN guidelines and illustrated through a detailed case study, the content provides nurses with practical frameworks for mastering technology-enabled tools, validated instruments like the Duke Activity Status Index, and health literacy practices to optimize surgical candidacy, prevent complications, and improve patient safety in ambulatory settings.