This learning activity provides a comprehensive overview of evidence-based approaches to managing chronic pain in pediatric populations. The content examines developmental considerations in pain assessment, age-appropriate pharmacological strategies, non-pharmacological and integrative interventions, and interdisciplinary care models. Emphasizing the unique challenges of pediatric pain management, the learning activity highlights the critical importance of developmental context, biopsychosocial frameworks, and family-centered care. Special attention is given to the nurse's role in assessment, medication administration, education, and care coordination across healthcare settings. The material is organized to enhance nursing practice with specific examples and evidence-based recommendations tailored to different developmental stages from infancy through adolescence.