This learning activity examines current evidence-based practices in pediatric infectious disease management, focusing on emerging pathogens such as norovirus GII.17 and avian influenza H5N1, evolving vaccination strategies including mRNA COVID-19 vaccines and RSV prevention with nirsevimab, and antimicrobial resistance challenges. The content integrates clinical assessment techniques, age-specific nursing interventions, infection prevention protocols, and family education approaches while addressing vaccine hesitancy through motivational interviewing and cultural competence. Designed for nurses working in pediatric settings, this educational resource emphasizes the unique considerations of developing immune systems, developmental variations in symptom presentation, and family-centered care approaches essential for managing infectious diseases across pediatric age groups from infancy through adolescence.