This comprehensive learning activity explores perinatal mood and anxiety disorders (PMADs) and the critical role nurses play in addressing these common complications of pregnancy and postpartum. The learning activity examines the spectrum of perinatal mental health conditions, evidence-based screening approaches, supportive nursing interventions, and treatment modalities. It emphasizes the unique position nurses occupy in early identification, providing first-line support, and facilitating appropriate treatment through interdisciplinary collaboration. The material integrates current clinical guidelines with practical application strategies to enhance nursing competence in delivering holistic, patient-centered perinatal mental health care.