This learning activity examines the expanding role of precision medicine in contemporary nursing practice, covering genomics-informed care, pharmacogenomics, cell and gene therapies, and digital health technologies. Nurses will explore how individual genetic variation affects drug metabolism and treatment selection, how to recognize and monitor toxicities unique to emerging therapies such as CAR-T, and how to communicate complex genomic information to patients in plain, actionable language. The activity also addresses equity, data privacy, and the ethical dimensions of precision medicine tools, equipping nurses across all practice settings to integrate these rapidly evolving technologies into safe, patient-centered care.