This comprehensive learning activity explores the critical issue of Ventilator-Associated Pneumonia (VAP) prevention in palliative care settings. It provides an in-depth overview of VAP, covering its pathophysiology, risk factors, and evidence-based prevention strategies. The learning activity emphasizes the importance of implementing VAP prevention bundles and discusses the unique considerations for applying these measures in palliative care contexts. It outlines key nursing responsibilities in VAP prevention, including patient assessment, implementation of preventive measures, and interdisciplinary collaboration. Special attention is given to balancing aggressive preventive measures with patient comfort and end-of-life care goals, making it particularly relevant for nursing professionals working in palliative care. Overall, the learning activity serves as a comprehensive educational resource for nurses seeking to enhance their knowledge and skills in preventing VAP while providing compassionate care to critically ill patients.