This learning activity provides a comprehensive overview of the key considerations and best practices for healthcare professionals, particularly nurses, involved in administering procedural sedation. It covers essential topics such as patient assessment, medication selection, monitoring, potential complications, and strategies for effective interprofessional collaboration. This learning activity emphasizes the importance of tailoring sedation plans to individual patient needs, vigilant monitoring, and prompt management of adverse events. It also highlights the critical role of teamwork, communication, and a culture of safety in optimizing outcomes for patients undergoing procedural sedation.