This comprehensive learning activity explores psoriatic disease, a chronic inflammatory condition affecting both skin and joints. It covers epidemiology, pathophysiology, clinical manifestations, diagnosis, and treatment options. The learning activity emphasizes the systemic nature of psoriatic disease and its impact on quality of life. It details various management strategies, including topical therapies, phototherapy, systemic medications, and biologic agents. The role of nurses in patient care is highlighted throughout, covering aspects such as assessment, medication administration, patient education, and psychosocial support. The learning activity also touches on emerging therapies and the importance of a multidisciplinary approach to care. It serves as a thorough resource for healthcare professionals, particularly nurses, in understanding and managing psoriatic disease.