Nurse call systems are a critical component of patient safety and quality care in healthcare settings. This learning activity examines how modern call systems function, including their key components such as patient call units, staff consoles, bathroom safety devices, and bed exit alarms. It explores strategies for prioritizing and responding to alerts effectively, addresses the risks of alert fatigue and the neurological basis behind it, and introduces current technology trends shaping call system design. Practical guidance on integrating call system response into daily care routines is emphasized throughout, with a focus on proactive rounding, clear communication, and thorough documentation. Upon completion, CNAs will be better equipped to respond to call alerts with confidence, consistency, and a commitment to patient-centered care.