This comprehensive learning activity examines sarcopenia—the progressive loss of skeletal muscle mass, strength, and function associated with aging—and its implications for nursing practice. The material covers the pathophysiology and clinical significance of sarcopenia, evidence-based assessment methods, prevention strategies, and management approaches. It details specific diagnostic criteria, assessment tools like handgrip strength measurement and gait speed evaluation, nutritional interventions including protein recommendations, and exercise protocols emphasizing resistance training. The content addresses medication considerations, patient education strategies, and the importance of interdisciplinary collaboration in caring for aging adults with this condition. Throughout, current guidelines from authoritative American health organizations are integrated with practical insights for registered nurses to enhance assessment skills and develop patient-centered interventions across healthcare settings.