This learning activity examines how telemedicine, wearable devices, and artificial intelligence are transforming pediatric nursing practice. Nurses learn to integrate remote monitoring for chronic conditions, continuous glucose and cardiac monitoring, and AI-driven clinical decision support with direct patient assessment while maintaining critical thinking and therapeutic relationships. The module emphasizes essential competencies including data privacy under HIPAA, adolescent confidentiality, recognizing algorithmic bias in diverse populations, and implementing technology safely according to Joint Commission standards. Special focus on health equity teaches nurses to identify and address access barriers facing vulnerable populations, ensuring technology enhances rather than replaces developmentally appropriate, family-centered care for all children.