This learning activity provides a comprehensive overview of Tourette Syndrome (TS) to educate healthcare providers on critical considerations surrounding assessment, diagnosis, treatment, and holistic management of this complex neurodevelopmental disorder. It outlines DSM-5 diagnostic criteria, delves into factors driving care disparities, offers patient-centered care optimization strategies for building therapeutic alliances, reviews behavioral and pharmacological symptom management evidence and options, highlights the need to address commonly co-occurring conditions for whole-person care, and summarizes key learning objectives with knowledge testing questions.