This learning activity examines nurses' unique work-life challenges and presents evidence-based strategies for sustainable practice. Beginning with the daily reality of nurses balancing competing demands, it notes 62% report burnout symptoms post-pandemic. It identifies nursing-specific challenges: 24/7 scheduling, emotional labor, and staffing shortages. Reframing the goal as "work-life integration" rather than perfect balance, it offers research-backed approaches including boundary management techniques, shift work adaptations, psychological resource strategies, and social support systems. The content emphasizes personalizing integration approaches to one's specialty, life stage, and temperament, positioning self-care as an ethical imperative directly linked to patient outcomes and clinical excellence.