This learning activity provides a comprehensive overview of thalassemias in obstetric care, covering pathophysiology, screening, diagnosis, and management throughout pregnancy. It details antenatal care strategies, potential complications, and their management for both mother and fetus. The learning activity also addresses intrapartum and postpartum care, neonatal considerations, psychosocial support, and patient education. It concludes with emerging therapies and emphasizes the role of nursing professionals in managing these complex cases.